Protein Query
Filter curated viral structures by virus, protein class, and ligand to build export-ready structure sets.
Open Protein QueryExplore viral protein-ligand structures, surface exposure, and degrader-readiness evidence from one curated workspace.
Select a virus, choose a PDB structure, inspect the bound ligand, and generate PyMOL sessions, ligand imagery, or query-ready outputs without leaving the V-LiSEMOD environment.
Visual Overview
See the complete V-LiSEMOD structure-to-design workflow.
The graphical abstract summarizes how the platform connects viral structures, interaction evidence, solvent exposure, linkability, PROTACability, and downstream design handoff.
01 Viral structures
02 Interaction analysis
03 Solvent-exposed atoms
04 Warhead linkability
05 PROTACability triage
06 Design handoff
Workflow Modules
Move between structure query, ligand comparison, and design triage in one workflow.
Ligand Indexer
Start from a ligand code or synonym and locate mapped PDB-chain-residue contexts.
Open Ligand IndexerLigand Comparison
Compare ligand interaction signatures across PDB structures and inspect warhead-relevant ligand contexts.
Open ComparisonPROTACability
Review warhead linkability, target lysine accessibility, structure priority, and degrader-readiness heuristics.
Open PROTACabilityPROTAC Builder
When you move from viral ligand analysis into degrader design, continue in the standalone external builder.
Open PROTAC Builder ↗
Project resources
Learn more without leaving the workflow
Explore methods, use cases, viral PROTAC design context, collaboration, and citation guidance.
Use cases
See how target-first, ligand-first, and degrader-oriented users work with V-LiSEMOD.
Read more →Viral PROTAC design
Understand the structural logic and limitations behind antiviral degrader concepts.
Read more →Methods overview
Review curation, interaction analysis, exposure mapping, and reproducibility framing.
Read more →Contact and collaboration
Reach out about scientific collaboration, software development, and dataset growth.
Read more →