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Prioritize viral protein structures for degrader-aware exploration.
Explore ligand-centered warhead linkability, target lysine accessibility, ternary geometry cues, and overall degrader-design readiness across curated viral protein structures. These metrics support hypothesis generation and do not replace experimental validation.
Warhead linkability evaluates whether the bound ligand contains solvent-exposed, chemically modifiable atoms that may tolerate linker attachment while preserving binding. Target lysine accessibility is evaluated separately as a ubiquitination-readiness cue. Ternary geometry cues are hypothesis-generating only and should not be interpreted as proof of productive degradation.
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Preparing grouped assessment summary.
Filter structural-priority results
Candidate small-molecule ligand contexts and higher-evidence warhead rows are prioritized by default. Glycan-only structures remain available for structural context, but they are not treated as strong warhead evidence.
Assessment results
Default view: target-first grouped cards so repeated PDB rows do not bury viral protein-level triage.
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